The Salisbury Highway starts as Route A13 in Elizabeth Vale, a north-eastern suburb of Adelaide along John Rice Avenue. It then runs parallel to Main North Road (Route A52) and crosses over Kings Road (Route A18). At Port Wakefield Road (National Highway A1), it changes status to National Highway A13 before ending at the intersection of the Port River Expressway (Route A9) and South Road. National Highway A13 then follows Main South Road to Grand Junction Road (Route A16 / National Highway A16), where it changes status to back to Route A13. It continues south along South Road, Main South Road and Victor Harbor Road, terminating at Victor Harbor on the south coast. It is 108 kilometres and a 1.36 hour drive.